Natural News, By: L.J. Devon, 11/24/2013
In the study, researchers looked at three kinds of colon cancer cells, p53(+/+), p53(-/-) HCT-116, and p53 HT-29. Cancer cell death was observed through curcumin's ability to reduce pro-caspase-3 levels, polymerase-1 cleavage and chromatin condensation. In a time- and dosage-dependent manner, curcumin caused wild-type p53 HCT-116 cells to self-destruct, while obliterating mutant p53 HT-29 cells in their tracks.
The researchers were so astounded that they proposed that curcumin may actually have therapeutic potential in the management of colon cancer. With its ability to inhibit the growth of neoplastic cells, curcumin is king against colon cancer. In the presence of curcumin, colon cancer cells went through a process of phosphorylation, which is a complete altering of the function and activity of certain protein enzymes. This was all for the better, as oxidative stress was alleviated and superoxide anion production was increased.
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